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Generators of fast oligonucleotide-sensing ribozyme with NOT or YES Boolean logic function

Programs’ interface. A. Generator for high-speed oligonucleotide sensing allosteric ribozymes with NOT logic function (GHOST-NOT). B. Generator for high-speed oligonucleotide-sensing allosteric ribozymes with YES logic function (GHOST-YES). The interphases are similar and comprised of several inputs like the length of the OBS to be generated, the temperature of 22 or 37oC, for which the ribozyme has to be generated, the number of the high-speed allosteric ribozymes to be created, and the minimum thermostability difference between the two generated states (ON and OFF).


We have created two computer programs for sequence generation of fast hammerhead allosteric ribozymes (with YES or NOT Boolean logic function that work under Linux/Unix. For the programs' installation guide click here. They are based on algorithms published in Nature Biotechnology and are written in Perl/Tk. The programs are free to use for academic research and you can apply for them by contacting us. The software is under the terms of the GNU General Public License as published by the Free Software Foundation; either version 3 of the License, or at your option any later version. GNU General Public License v3.0 form - GNU Project - Free Software Foundation. That research is funded by grant KP-06-H31/18/13.12.2019 awarded by the Bulgarian National Science Fund (BNSF). This research is published in Journal of Biotechnology.