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Robert Penchovsky's Website

  

  

Robert's Research

• Computational Design of Allosteric Ribozymes

  that function as Boolean logic gates in vitro and in vivo…

• Engineering Gene Regulatory Networks

  for exogenous control of gene expression and gene therapy…

• Design and Analyses of Non-coding RNAs

  investigating the role of non-coding RNAs in gene regulation…

• Molecular Computing

  employing nucleic acids as molecular computing devices…

• Ribozyme-based Molecular Circuit

  as programmable nanodevices…

• Computational Drug Design

  applying virtual high- throughput screening assays and rational design…

• High-throughput Screening Assays

  for antibacterial drug discovery employing RNA targets…

• Targeting specific RNAs by antisense oligonucleotides

  Inhibition of bacterail growth by targeting specific RNAs by antisense oligo- nucleotides (ASOs)…

• Design of Programmable Microfluidic Devices

  for fully automated biochemical microarrays and biosensors…

• Software Design for Bionformatics

  15 essential and very useful bioinformatics applets, bioinformatics database, and programs for design of allosteric ribozymes…

Main Grant Awards

• grant:DDVU02/5/2010

  Design and applications of RNA biosensors in vitro and in vivo…

• grant:DN13/14/20.12.2017

  Design and experimental validation of chimeric antisense oligo- nucleotides as antibacterial agents…

• grant:KP-06-H31/18/13.12.2019

  Engineering functional nucleic acids for synthetic control of gene expression in pro- karyotes & eukaryotes...

• grant:KP-06-H63/1/13.12.2022

  Comparative analysis of the effectiveness of new antibacterial agents based on different types of antisense oligonucleotides using different molecular mechanisms of RNA inhibition...

• grant:4011/05.07.2023

  Design of Antisense Oligonucleotides Linked to Cell Penetrating Oligopeptides as New Antibacterial Agents Against Resistant Human Pathogenic Bacteria for European Patent Application...

• grant:70-123-194/12.02.2024

  Creation of software systems for computer-aided design of rapid allosteric ribozymes that sense the presence of sequence-defined oligonucleotides and a database of clinically relevant human genetic variation (budget: 102300 EURO )...

Research Awards

• Dr. Penchovsky's outstanding scientist award, 2023

  7^th Edition of International Research Awards on SENSING TECHNOLOGY…

• Dr. Penchovsky's award from the Bulgarian national contest, 2015

  for scientific excellence for researchers of all areas over 35 years old organized by the Union of the Scientists in Bulgaria…

Awards for PostDocs

• a young microbiologist national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

  Dr. Martina Traykovska won an award for first place…

• a young microbiologist in a national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

  Dr. Nikolet Pavlova won an award for second place…

PhD students' Awards

• an award from the contest student of the year 2022 of Sofia University

  our doctoral student Georgi Miloshev won the prize doctoral student of the year 2022 of Sofia University…

• an award from the national contest "Young and Energetic Scientists", 2021

  our doctoral student Antoniya Georgieva won a first prize in the Ph.D. category…

Poster awards

• Sofia Science Festival, May 15-16, 2021

  see our acknowledged poster and research project RD-22-838/2020 by BMES…

• an award from the Congress of Micro- biologists in Bulgaria with International Participation, Hisara 2018

  see our award winning posters…

Another awards

• an award from the of the EWA 2022 Start-up Competition in Bulgaria, 2022

  My doctoral student Antoniya Georgieva won a second place…

• an award for teacher of the year for 125 School, Sofia, 2022

  My doctoral student Georgi Miloshev won the teacher’s prize of the year…

• an award for a contribution to the biology education of Sofia, 2023

  My doctoral student Georgi Miloshev was awarded by the Bulgarian Ministry of Education and Science…

News and views on us

• Homo Sciens

  PROF. ROBERT PENCHOVSKY:THE SCIENTIST WHOSE ACHIEVEMENTS BOLDLY LEAD THE WAY TOWARDS THE FUTURE by Prof. Radostina Alexandrova, October 2023…

• Robert's live interview for the Bulgarian National Radio about his upcoming talk on the Sofia Science Festival,

  given in Bulgarian on the May 4, 2023…

• Our lab members' interview for Science_BG: video,

  given in Bulgarian on April 28, 2023…

• Homo Sciens

  GEORGI MILOSHEV: THE SCIENTIST TEACHER WHO INVESTS IN THE THINGS HE DOES A PIECE OF HIS HEART by Prof. Radostina Alexandrova, October 2023…

• Nature Biotechnology

  Boolean calculations made easy (for ribozymes)…

• Nature Methods

  'Computational evoluation' offers riboswitch solution..

• ACS Synthetic Biology

  Authors' Biopraphy…

• RSC Chemistry World

  When is an enzyme not a protein?…

• Sofia University

  Distinction for Prof. Dr. Robert Penchovsky from the Faculty of Biology…

• YearBoook of Research Projects at Sofia University

  Design and experimental validation of chimeric antisense oligo- nucleotides as antibacterial agents…

• Magazine of Bulgarian Science

  interview with Martina Traykovska…

• Sofia University

  results of grant "Design and experimental validation of chimeric antisense oligonucleotides as antibacterial agents"…

• Bulgarian National Science Fund

  results in Bulgarian of grant:DN13/14/20.12.2017…

• Bulgarian Ministry of Education and Science

  results of grant:DN13/14/20.12.2017…

• Magazine of Bulgarian Science

  results in Bulgarian of grant:DN13/14/20.12.2017…

• Interview with Prof. Draga Toncheva for the Bulgarian National Radio

  broadcasted in Bulgarian on September 8, 2017…

• Robert's interview for Science_BG: video,

  given in Bulgarian on March 2, 2022…

• Martina's short interview for Science_BG: video,

  on YouTube on June 6, 2021…

• Robert's interview for Science_BG: podcast,

  given in Bulgarian on March 2, 2022…

• Robert's interview for the Bulgarian National Radio

  broadcasted in Bulgarian on March 24, 2022…

• News papers on us in Science_BG in Bulgarian, March, 2023

  Four young scientists working under the supervision of rof. Robert Penchovsky won 5 different awards since 2021.…

• News on the main website of Sofia University in Bulgarian, March, 2023

  Four young scientists working under the supervision of Prof. Robert Penchovsky won different awards.…

• News on the main website of Sofia University in English, April, 2023

  Four young scientists working under the supervision of Prof. Robert Penchovsky won different awards.…

• News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in Bulgarian, March, 2023

  Martina Traykovska and Nikolet Pavlova, working under suppervision of Prof. Penchovsky, won first and second awards.…

• News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in English, March, 2023

  Martina Traykovska and Nikolet Pavlova, working under suppervision of Prof. Penchovsky, won first and second awards.…

• Our recent paper is an editors' choice of the American Chemical Society. That is huge!

  Engineering antisense oligonucleotides as antibacterial agents that target FMN riboswitches and inhibit the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli …