Robert Penchovsky:Research

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You can see the topics of my research below.

Robert's Research

Computational Design of Allosteric Ribozymes

that function as Boolean logic gates in vitro and in vivo…
Engineering Gene Regulatory Networks

for exogenous control of gene expression and gene therapy…
Design and Analyses of Non-coding RNAs

investigating the role of non-coding RNAs in gene regulation…
Molecular Computing

employing nucleic acids as molecular computing devices…
Ribozyme-based Molecular Circuit

as programmable nanodevices…
Computational Drug Design

applying virtual high- throughput screening assays and rational design…
High-throughput Screening Assays

for antibacterial drug discovery employing RNA targets…
Targeting specific RNAs by antisense oligonucleotides

Inhibition of bacterail growth by targeting specific RNAs by antisense oligo- nucleotides (ASOs)…
Design of Programmable Microfluidic Devices

for fully automated biochemical microarrays and biosensors…
Software Design for Bionformatics

15 essential and very useful bioinformatics applets, bioinformatics database, and programs for design of allosteric ribozymes…

You can see the laboratory's members.

Lab's members

Professor Robert Penchovsky, Ph.D.

head of the laboratory - CV…
Assistant Professor Martina Traykovska, Ph.D.

teaching and research - CV…
Assistant Professor Nikolet Pavlova, Ph.D.

teaching and research- CV…
researcher Dimitrious Kaloudas, Ph.D.

research - CV…
Antoniya Georgieva, M.Sc.

doctoral student…
Vanya Dyakova, M.Sc.

doctoral student…

You can see main research grants.

Main Grant Awards

grant:DDVU02/5/2010

Design and applications of RNA biosensors in vitro and in vivo…
grant:DN13/14/20.12.2017

Design and experimental validation of chimeric antisense oligo- nucleotides as antibacterial agents…
grant:KP-06-H31/18/13.12.2019

Engineering functional nucleic acids for synthetic control of gene expression in pro- karyotes & eukaryotes...
grant:KP-06-H63/1/13.12.2022

Comparative analysis of the effectiveness of new antibacterial agents based on different types of antisense oligonucleotides using different molecular mechanisms of RNA inhibition...
grant:4011/05.07.2023

Design of Antisense Oligonucleotides Linked to Cell Penetrating Oligopeptides as New Antibacterial Agents Against Resistant Human Pathogenic Bacteria for European Patent Application...
grant:70-123-194/12.02.2024

Creation of software systems for computer-aided design of rapid allosteric ribozymes that sense the presence of sequence-defined oligonucleotides and a database of clinically relevant human genetic variation (budget: 102300 EURO )...

You can see our awards.

Research Awards

Dr. Penchovsky's outstanding scientist award, 2023

7^th Edition of International Research Awards on SENSING TECHNOLOGY…
Dr. Penchovsky's award from the Bulgarian national contest, 2015

for scientific excellence for researchers of all areas over 35 years old organized by the Union of the Scientists in Bulgaria…

You can see our awards.

Awards for PostDocs

a young microbiologist national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

Dr. Martina Traykovska won an award for first place…
a young microbiologist in a national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

Dr. Nikolet Pavlova won an award for second place…

You can see our awards.

PhD students' Awards

an award from the contest student of the year 2022 of Sofia University

our doctoral student Georgi Miloshev won the prize doctoral student of the year 2022 of Sofia University…
an award from the national contest "Young and Energetic Scientists", 2021

our doctoral student Antoniya Georgieva won a first prize in the Ph.D. category…

You can see our awards.

Poster awards

Sofia Science Festival, May 15-16, 2021

see our acknowledged poster and research project RD-22-838/2020 by BMES…
an award from the Congress of Micro- biologists in Bulgaria with International Participation, Hisara 2018

see our award winning posters…

You can see our awards.

Another awards

an award from the of the EWA 2022 Start-up Competition in Bulgaria, 2022

My doctoral student Antoniya Georgieva won a second place…
an award for teacher of the year for 125 School, Sofia, 2022

My doctoral student Georgi Miloshev won the teacher’s prize of the year…
an award for a contribution to the biology education of Sofia, 2023

My doctoral student Georgi Miloshev was awarded by the Bulgarian Ministry of Education and Science…

News and views on our research.

News and views on us

Homo Sciens

PROF. ROBERT PENCHOVSKY:THE SCIENTIST WHOSE ACHIEVEMENTS BOLDLY LEAD THE WAY TOWARDS THE FUTURE by Prof. Radostina Alexandrova, October 2023…
Robert's live interview for the Bulgarian National Radio about his upcoming talk on the Sofia Science Festival,

given in Bulgarian on the May 4, 2023…
Our lab members' interview for Science_BG: video,

given in Bulgarian on April 28, 2023…
Homo Sciens

GEORGI MILOSHEV: THE SCIENTIST TEACHER WHO INVESTS IN THE THINGS HE DOES A PIECE OF HIS HEART by Prof. Radostina Alexandrova, October 2023…
Nature Biotechnology

Boolean calculations made easy (for ribozymes)…
Nature Methods

'Computational evoluation' offers riboswitch solution..
ACS Synthetic Biology

Authors' Biopraphy…
RSC Chemistry World

When is an enzyme not a protein?…
Sofia University

Distinction for Prof. Dr. Robert Penchovsky from the Faculty of Biology…

YearBoook of Research Projects at Sofia University

Design and experimental validation of chimeric antisense oligo- nucleotides as antibacterial agents…
Magazine of Bulgarian Science

interview with Martina Traykovska…
Sofia University

results of grant "Design and experimental validation of chimeric antisense oligonucleotides as antibacterial agents"…

Bulgarian National Science Fund

results in Bulgarian of grant:DN13/14/20.12.2017…
Bulgarian Ministry of Education and Science

results of grant:DN13/14/20.12.2017…
Magazine of Bulgarian Science

results in Bulgarian of grant:DN13/14/20.12.2017…
Interview with Prof. Draga Toncheva for the Bulgarian National Radio

broadcasted in Bulgarian on September 8, 2017…
Robert's interview for Science_BG: video,

given in Bulgarian on March 2, 2022…
Martina's short interview for Science_BG: video,

on YouTube on June 6, 2021…
Robert's interview for Science_BG: podcast,

given in Bulgarian on March 2, 2022…
Robert's interview for the Bulgarian National Radio

broadcasted in Bulgarian on March 24, 2022…
News papers on us in Science_BG in Bulgarian, March, 2023

Four young scientists working under the supervision of rof. Robert Penchovsky won 5 different awards since 2021.…
News on the main website of Sofia University in Bulgarian, March, 2023

Four young scientists working under the supervision of Prof. Robert Penchovsky won different awards.…
News on the main website of Sofia University in English, April, 2023

Four young scientists working under the supervision of Prof. Robert Penchovsky won different awards.…
News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in Bulgarian, March, 2023

Martina Traykovska and Nikolet Pavlova, working under suppervision of Prof. Penchovsky, won first and second awards.…
News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in English, March, 2023

Martina Traykovska and Nikolet Pavlova, working under suppervision of Prof. Penchovsky, won first and second awards.…
BGlobal, in Bulgarian, July, 2023

A microbiologist replaces antibiotics when they do not work.…
Our recent paper is an editors' choice of the American Chemical Society. That is huge!

Engineering antisense oligonucleotides as antibacterial agents that target FMN riboswitches and inhibit the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli …

Grant:4011/05.07.2023, Design of Antisense Oligonucleotides Linked to Cell Penetrating Oligopeptides as New Antibacterial Agents Against Resistant Human Pathogenic Bacteria for European Patent Application, awarded to Prof. Robert Penchovsky, Ph.D.

The main goal of this project is to continue a very successful research in the field of RNA synthetic and computational biology, medicine and pharmacy started by the project leader Prof. Robert Penchovsky, Ph.D., Faculty of Biology to developed and patent new antibacterial agents based on antisense oligonucleatides.
The budget of the project is 102 250 EUR.

Robert Penchovsky's Website

Robert's Research

Computational Design of Allosteric Ribozymes

Engineering Gene Regulatory Networks

Design and Analyses of Non-coding RNAs

Molecular Computing

Ribozyme-based Molecular Circuit

Computational Drug Design

High-throughput Screening Assays

Targeting specific RNAs by antisense oligonucleotides

Design of Programmable Microfluidic Devices

Software Design for Bionformatics

Lab's members

Professor Robert Penchovsky, Ph.D.

Assistant Professor Martina Traykovska, Ph.D.

Assistant Professor Nikolet Pavlova, Ph.D.

researcher Dimitrious Kaloudas, Ph.D.

Antoniya Georgieva, M.Sc.

Vanya Dyakova, M.Sc.

Main Grant Awards

grant:DDVU02/5/2010

grant:DN13/14/20.12.2017

grant:KP-06-H31/18/13.12.2019

grant:KP-06-H63/1/13.12.2022

grant:4011/05.07.2023

grant:70-123-194/12.02.2024

Research Awards

Dr. Penchovsky's outstanding scientist award, 2023

Dr. Penchovsky's award from the Bulgarian national contest, 2015

Awards for PostDocs

a young microbiologist national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

a young microbiologist in a national contest by the Foundation of Acad. Prof. Stephan Angeloff, 2023

PhD students' Awards

an award from the contest student of the year 2022 of Sofia University

an award from the national contest "Young and Energetic Scientists", 2021

Poster awards

Sofia Science Festival, May 15-16, 2021

an award from the Congress of Micro- biologists in Bulgaria with International Participation, Hisara 2018

Another awards

an award from the of the EWA 2022 Start-up Competition in Bulgaria, 2022

an award for teacher of the year for 125 School, Sofia, 2022

an award for a contribution to the biology education of Sofia, 2023

News and views on us

Homo Sciens

Robert's live interview for the Bulgarian National Radio about his upcoming talk on the Sofia Science Festival,

Our lab members' interview for Science_BG: video,

Homo Sciens

Nature Biotechnology

Nature Methods

ACS Synthetic Biology

RSC Chemistry World

Sofia University

YearBoook of Research Projects at Sofia University

Magazine of Bulgarian Science

Sofia University

Bulgarian National Science Fund

Bulgarian Ministry of Education and Science

Magazine of Bulgarian Science

Interview with Prof. Draga Toncheva for the Bulgarian National Radio

Robert's interview for Science_BG: video,

Martina's short interview for Science_BG: video,

Robert's interview for Science_BG: podcast,

Robert's interview for the Bulgarian National Radio

News papers on us in Science_BG in Bulgarian, March, 2023

News on the main website of Sofia University in Bulgarian, March, 2023

News on the main website of Sofia University in English, April, 2023

News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in Bulgarian, March, 2023

News on a young microbiologist national awards on website of the Institute of Microbiology, BAS, in English, March, 2023

BGlobal, in Bulgarian, July, 2023

Our recent paper is an editors' choice of the American Chemical Society. That is huge!

Grant:4011/05.07.2023, Design of Antisense Oligonucleotides Linked to Cell Penetrating Oligopeptides as New Antibacterial Agents Against Resistant Human Pathogenic Bacteria for European Patent Application, awarded to Prof. Robert Penchovsky, Ph.D.